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Results for " HY-17403 " in MedChemExpress (MCE) Product Catalog:

Inhibitors & Agonists

Cat. No. Product Name Target Research Area
  • HY-17403
    Manidipine dihydrochloride Calcium Channel; NF-κB Cardiovascular Disease; Inflammation/Immunology; Metabolic Disease; Infection
    Manidipine dihydrochloride is a third-generation, lipophilic, orally active and highly vasoselective calcium channel antagonist (IC50 = 2.6 nM in guinea-pig ventricular cells) and acts as an antihypertensive agent. Manidipine effectively reduces blood pressure as well as improving insulin sensitivity, renal protection, and antiatherosclerotic activity. Manidipine also exerts anti-inflammatory activity mediated by NF-κB and antiviral activity against many flavivirus and negative-strand RNA viruses through the inhibition of calcium channel. Manidipine is widely applied to research of cardiovascular, metabolic disease and infection[1][2][3][4][5][6].

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